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In addition, one may terminate the trial due to insufficient effects.
This in turn may have led to insufficient effects of analgesics.
However, the use of immunotherapy to modify potential sites of the LPS/TLR-4 signaling pathway showed insufficient effects [ 36].
First, we consider a study that is terminated early due to insufficient effects if p1 ≥ α0 = 0.5.
38– 41 Such interventions may have had insufficient effects on functional capacity, or an insufficient number of participants have managed to become independent in dressing or transfer.
It is recommended to apply the TPM rather than Fisher's combination test whenever an early termination due to insufficient effects is not suitable within the adaptive design.
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Many of the patients who experience an insufficient effect of simple analgesics have good effect from triptans [10].
In case of insufficient effect or unacceptable side effects, neurosurgical treatment using microvascular decompression or lesion treatment should be considered.
Although prophylactic pharmacological treatment is first choise, considering of insufficient effect or unacceptable side effects, neurosurgical treatment or lesion treatment should be considered.
In case of insufficient effect or unacceptable side effects, neurosurgical treatment using microvascular decompression or lesion treatment should be considered [5].
Table 1 Antibacterial effect assessment for different nanofiber membranes [82] Sample groups Bacteria growth Antibacterial activity Cotton gauze Moderate growth Insufficient effect PVA-crosslinked No growth Good effect PVA-Ag No growth Very good effect PVA-p-cospin Slight growth Limit of efficacy PAN No growth Good effect PAN-PEU No growth Good effect PVdF-HFP Heavy growth Insufficient effect.
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