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Insufficient depletion can be seen on retreatment with documented very rapid clearance of rituximab in association with a marked human anti-chimaeric antibody response [ 42].
Insufficient depletion of peritoneal B1 cells is thought to be due to the lack of effector cells in the peritoneal space [ 33].
Whether factors such as insufficient depletion of native PCNA or the use of different genotoxic agents are responsible for these discrepancies remains to be determined.
Suppression of either MASTL or ESPL1 did not alter the chromosome morphology, which may relate to an insufficient depletion by RNAi.
The reason why the taxonomic distribution of sequences is little changed following normalization is not evident from our results, but one possible explanation is that compression of taxonomic distribution could not achieved due to insufficient depletion of rRNA variation.
Again, to what extent this may indicate less susceptibility and insufficient depletion of memory B-cell subsets in association with no response or with a shorter response is not known.
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Obesity is associated with an increased body aromatisation and may be a cause of insufficient estradiol depletion.
This is consistent with the possibility that replication stress caused by insufficient dNTPs during nutrient depletion can trigger apoptosis.
This report focused on hypotheses derived from a computer model of the interaction of various global socioeconomic trends; it projected a Malthusian vision in which the collapse of world order would result if population growth, industrial expansion, and increased pollution, combined with insufficient food production and the depletion of natural resources, were to continue at current rates.
Another complicating factor is whether a low plasma concentration really is indicative of depletion and an insufficient antioxidant defense in critical illness.
Stem cell depletion leads to insufficient replacement of epithelial cells in the upper crypt and villus, causing denudation of the mucosa.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com