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Nucleic-acid-based drugs are a promising class of novel therapeutics; however, their use in medicine is widely limited because of insufficient delivery into cells.
Lissencephaly is caused by abnormalities in the migration of neurons in embryonic development, which in turn may be caused by genetic mutations, viral infection of the fetus or uterus, or insufficient delivery of blood to the embryonic brain.
Insufficient delivery of CO2 into the nasal cavity seems unlikely as changes of pCO2 levels after nasal insufflation did not correlate with pain ratings in our pilot study.
Insufficient delivery of chemotherapeutic agents to their intended molecular targets remains a major obstacle in clinical oncology.
Almost all centres reported they had insufficient delivery kits, scales, stehtoscopes, sphygmomanometers, tongue pressers, and sphygmomanometers for children.
Insufficient delivery of health-promotion and patient-education messages were considered a form of CI as well.
Similar(42)
The main reason for the shortage of drugs was insufficient deliveries from the Regional Medical Store.
The main reason for the observed shortage of drugs at health centre level was insufficient deliveries from the Regional Medical Store.
The main reason for the observed shortage of drugs at the health centres was insufficient deliveries from the Regional Medical Store.
It was found that the main reason for the observed shortage of drugs at health centre level was insufficient deliveries from the Regional Medical Store (see Table 1 and first row in Table 2).
However, insufficient brain delivery to yield beneficial central without peripheral side effects have prevented clinical development in most instances.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com