Among the shortcomings are time dependence, susceptibility to errors in scanner and dose calibration, insufficient correlation between systemic distribution volume and body weight, and, consequentially, residual inter-study variability of the arterial input function (AIF) despite SUV normalization.
Insufficient correlation between systemic distribution volume and body weight (leading to variants of the SUV approach using lean body mass (SUV l b m ) [4] or body surface area (SUV b s a ) [5] for normalization), and, consequentially, residual inter-study variability of the arterial input function (AIF) despite SUV normalization [6]. 3.
Susceptibility to errors in scanner calibration, Insufficient correlation between systemic distribution volume and body weight (leading to variants of the SUV approach using lean body mass (SUV l b m ) [4] or body surface area (SUV b s a ) [5] for normalization), and, consequentially, residual inter-study variability of the arterial input function (AIF) despite SUV normalization [6].
Although various CE-marked commercial kits are available, a recent comparison showed significant differences between kits and an insufficient correlation to the values of the 1st International Reference Preparation (Kennerkuecht et al. submitted).
Furthermore, due to variable interobserver agreement, insufficient correlation with MGMT promoter methylation status and the lack of a firm association with patient outcome [ 20, 29, 103], MGMT IHC has not proved to be a clinically usable biomarker for routine diagnostic purposes and clinical decision-making.
47 There could therefore be insufficient correlation between changes in drinking behaviour and alcohol consumption with patient-perceived impact on health status using this measure, which could have led to an underestimation of the QALY gains for nalmefene in this analysis.
There are insufficient genotype phenotype correlations in FHM, according to the different possible mutations.
Although recently developed array-based technology has been applied to UCs (13– 18), the resolution of the arrays employed was insufficient or correlations between copy number alterations and the clinicopathological parameters of UCs were not analyzed in detail.
An insufficient item total correlation is assumed if the item total correlation ritt is lower than 0.20 [ 33].
The rules include: ① Rule 1 If the number of samples is sufficient, the distribution counting is strictly conducted on the corresponding data from questionnaires; ② Rule 2 If the number of samples is insufficient, the correlation between features is ignored and the independent distribution of the corresponding feature is used directly.
