Even if samples with the same allele frequencies are simulated, the individuals generated may not have enough genetic variations to allow adequate modeling with a GxE model because of insufficient combinations of genetic and environmental factors.
Hence, while miR-21 inhibition or TMZ alone may be insufficient, their combination may significantly enhance cancer stem cell death (Zhang et al, 2012).
Because smear layer removal capacity of this solution is insufficient, a combination of boric and citric acid solutions can be mixed for clinical use in order to achieve antimicrobial effect and smear layer removal capacity at the same time.
In cases in which circulatory improvement was judged to be insufficient with this combination (i.e. persistent and severe left ventricular systolic dysfunction by echocardiography), dobutamine was replaced by adrenaline (epinephrine) infusion at 0.5 2 μg/kg per minute [ 7].
In relay-assisted systems, greedy algorithms are used in [16, 17] to search for the best set of relays; however, with insufficient numbers of combinations considered, a significant performance loss is experienced as compared to an exhaustive search.
That shift is likely to help borrowers like Ivy Brodsky, 37, who was charged $1,523 in fees — a combination of insufficient funds, service fees and overdraft fees — in a single month after six Internet payday lenders tried to withdraw money from her account 55 times.
"At our location in Dartford we have advised employees of our proposal to close this location due to a combination of insufficient construction activity and a disproportionately high cost base," Balfour Beatty said.
The effectiveness of measures targeted at the restoration of populations of endangered species in anthropogenically dominated regions is often limited by a combination of insufficient restoration of habitat quality and dispersal failure.
In further studies, low vitamin D levels doubled the risk of being in hospital for more than 14 days in a geriatric acute care unit [22], and the combination of insufficient 25-OH-D level, male gender and delirium predicted a 4.8-fold higher risk of longer length of stay among geriatric inpatients [23].
This model proposes that excessive musculoskeletal stress (two or three training sessions per day for several weeks) in combination with insufficient recovery (sleep, nutrition, psychological down time) leads to chronic musculoskeletal inflammation and the release of the following pro-inflammatory cytokines: interleukin-6 (IL-6), interleukin-1-beta (IL-1β), and tumor necrosis factor-alpha (TNF-α).
