Sentence examples for insufficient bioavailability from inspiring English sources
However, this strategy faces many challenges, including instability in the gastrointestinal (GI) tract, insufficient bioavailability, low tumor targeting, and severe adverse effects.
The optimum potential of curcumin is limited because of poor oral bioavailability and insufficient solubility in aqueous solvents leading to poor absorption, fast metabolism, and quick systemic elimination [ 5, 93].
Epinephrine has a very low oral bioavailability which makes this form insufficient for therapeutic use [ 3– 6].
Thus, the bioavailability of rapamycin might be at an insufficient level in the embryos.
61 Endothelial dysfunction in diabetes is manifested as the decreased bioavailability of nitric oxide (NO), resulting in insufficient relaxation of the vascular smooth muscle of the corpora cavernosa.
The RELAX investigators speculated that the ability of phosphodiesterase-5 inhibitors to enhance cGMP might be limited by insufficient endogenous stimulation of sGC secondary to reduced NO bioavailability in HFpEF.
Thus, the observed differences in chemical property space between antibacterials and nonantiinfectives explain why rules for predicting oral bioavailability for drugs with eukaryotic targets are insufficient for predicting cell permeability in bacteria.
Since the brain bioavailability of many compounds is low due to insufficient blood brain barrier penetration, we determined whether anle138b supplemented in food pellets effectively passes the blood brain barrier.
It has been hypothesized that due to reduced bioavailability, low doses of enteric-coated ASA may be insufficient in heavier patients with a larger volume of distribution [ 34].
Normally they have very low bioavailability," he says.
