Sentence examples for insufficient binding from inspiring English sources

For such flexible disordered regions, we speculate that the relatively small size of the antibody binding site provides insufficient binding energy to fold the flexible disorder and therefore cannot bind tightly enough for the generation of an immune response.

Beside radical scavenging, the components may influence the structure of the laccase, resulting in insufficient binding of the substrate in the active site, and consequently in less transformation.

This may be mainly attributed to the insufficient binding between the perovskite particles in the film, which has presumably resulted in excessive charge recombination, due to an inadequate charge transfer from the perovskite to the adjacent layers (TiO2 and spiro-OMeTAD).

Similarly, the HA 226 residue, critical to cell tropism in human H3 and H9N2, has been shown to be an insufficient binding site for determining the receptor tropism of the human H1, H2, H5 and the avian H6, H9 and H5N1 viruses [4], [33], [34], [35].

Tables S1 and S2 list all best-fit cases for the two-step and sequential models respectively, along with a summarized classification of individual Ly49-MHC class I interactions as displaying either no binding ("no"), insufficient binding to pass selection ("insuff") or sufficient binding to pass selection in itself ("suff").

This is because insufficient binding (e.g., nonspecific cargoes) implies rejection.

For instance, the PH domain of APPL1 alone is insufficient for binding to the membrane (Miaczynska et al, 2004).

The BD alone was insufficient for binding any of the nucleosomes, but in the presence of the PHD and H3K4me3, selective interaction with H4K16ac-containing nucleosomes was observed.

This result suggests that a HN phenotype with insufficient receptor-binding affinity was obtained at elevated temperature.

EGF domain is well-known to be functional in ligand recognition and cell adhesion [2], since Lec domain alone does support leukocyte adhesion but is insufficient for maximal binding whereas the concurrence of Lec and EGF (LE) domains constitutes the optimal recognition unit for leukocyte binding [3].

Phosphorylation of 4E-BP1 at Ser65 and Thr70 is insufficient to prevent binding to eIF4E.