Distributions of clinical measures associated with functional status often contain extraneous and/or insufficient variation associated with outliers or clustering hence, transformation of the associated scores is a commonly utilized strategy to make a measure more useful for its intended purpose [ 24].
This technology permitted us to avoid the insufficient expression associated with more severe consequences, such as lethality, and provided advantages similar to those obtained with mutations generating hypomorphic phenotypes.
ALPPS is indicated based on anticipated FLR volume: in general, the procedure may be offered when pre-operative volumetry predicts an insufficient FLR associated with major liver tumour and/or additional liver pathology (including chemotherapy-induced damage, fibrosis, cholestasis or macrosteatosis) [25].
The health consequences of just a week of mild sleep deprivation can be seen in the current study and in other research, which shows insufficient sleep associated with diminished cognitive performance, reduced alertness and mood problems.
The latter drug is the most widely used disease-modifying antirheumatic drug but, despite a favourable efficiency toxicity profile, in numerous patients it is either insufficient or associated with unacceptable side effects.
Similarly, there is currently insufficient data to associate cytokine production in the bone marrow with MGUS in Gaucher patients.
The present study has some limitation; the number of patients studied was insufficient to definitively associate postsurgical hypoparathyroidism with increased fracture risk.
Moreover, several meta-analyses have addressed the epidemiological data pertaining to both NPC and leukemia and concluded that there are insufficient data to associate formaldehyde with these diseases.
These interactions are known to be weak, and are usually insufficient to stably associate proteins with the membrane under physiological conditions, requiring coupling to additional membrane-targeting motifs (Mulgrew-Nesbitt et al., 2006).
The committee's two main conclusions were that (1) there is insufficient evidence to associate non-phenacetin combined analgesics with nephropathy and that (2) new studies should be done to provide appropriate data to resolve the question [ 5].
