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Vitamin D deficiency and insufficiency were defined as a serum 25-hydroxyvitamin D concentration < 10 ng/mL and 10 30 ng/mL, respectively.
Because angiotensin receptor blockers are often prescribed to people with renal insufficiency, we examined a separate model incorporating renal disease as a covariate; people with renal insufficiency were defined as those with glomerular filtration rates of less than 60 ml/min using a formula defined by the Renal Disease Study Group.
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Respiratory insufficiency was defined as SpO2 below 85% or notes in the chart indicating "insufficient breathing," "cyanosis," etc. Insufficient circulation was defined as a SAP <90 mm Hg.
Venous insufficiency was defined as characteristic clinical findings and duplex findings of either reflux or thrombus in the deep or superficial system.
Currently, vitamin D insufficiency is defined as serum level ranges between 21 and 29 μg/l, a serum level below <20 μg/l as vitamin D deficiency (severe deficiency <10 μg/l) [22, 25, 26].
Adrenal insufficiency is defined as primary or secondary.
Adrenal insufficiency was defined by a response ≤9 g/dl.
Pancreatic insufficiency was defined as supplementation with oral pancreatic enzymes.
Insufficiency was defined as <30 ng/ml, by the local laboratory standard used in Oregon.
Relative adrenal insufficiency was defined as stimulated cortisol less than 18 μg/dl.
Respiratory insufficiency was defined as necessity for noninvasive ventilation or mechanical ventilation.
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