But there is a great probability of catastrophic failures such as mechanical jamming or insufficiency in the mechanisms when closing the valve in working condition.
This argues against a haplo-insufficiency pathological mechanism, with the caveat that additional mutational classes may be found as more HSP families are screened for strumpellin mutations.
The degenerative effect of DM on neurons and nerves is explained by microvascular insufficiency and biochemical mechanisms [ 11].
This suggests that, rather than folate insufficiency, a different mechanism, such as systemic inflammation, may lead to increased PBL DNA methylation.
However, these patients often had hepatic cirrhosis, hepatic insufficiency, and clotting mechanism disorder, which are intolerable with hepatic tissue biopsy.
Overproduction of ROS and insufficiency of antioxidant mechanism results in an oxidative stress condition, which directly damages cell structures and molecules, including lipids, proteins and DNA [ 10].
A wide diversity of clinically relevant pharmacokinetic interactions are due to modifications of CYP450 system; transmembrane pump, hepatic or renal insufficiency, as well as mechanisms still being elucidated.
On the other hand, the injury might embrace autoimmune mechanisms, neurovascular insufficiency, deficient neurotrophism, oxidative and nitrosative stress, and inflammation.
Infection of the placenta, placental insufficiency caused by immunological mechanisms, and direct effects on the foetus may all be contributing factors [ 4].
In fact, placental insufficiency is the primary mechanism through which intrauterine crowding of fetuses decreases fetal survival [ 10].
