If one looks at relative adrenal insufficiency in terms of nonresponders to ACTH (≤ 9 g/dl), then the mortality in that group was 72%, whereas in those who did respond to ACTH the mortality was 32% – more than double.
Following documentation of the advantages of using ECMO to manage neonatal respiratory insufficiency in terms of both mortality and morbidity, the evaluation of pharmacotherapy during neonatal ECMO should become a second step toward a more evidence-based approach to these patients.
ABC revealed insufficiencies in terms of data completeness, and ABC and FES(S) had many outliers when comparing t1 and t2.
However, currently no LF inhibitor is available on the market as a therapeutic, partly due to the insufficiency of existing LF inhibitor scaffolds in terms of efficacy, selectivity, and toxicity.
In terms of this insufficiency, it is not surprising to see the low incidence of nuchal rigidity [ 1].
A previous study showed that completeness of patients' problem list in terms of renal insufficiency in one network was only 4.7%, which is lower than that for hypertension, diabetes, and breast cancer [ 7].
These patients cannot actively exercise due to cardiac and respiratory insufficiency, so they benefit from EMS in terms of exercise capacity [ 20- 22], skeletal muscle performance [ 19, 20, 22] and quality of life [ 19, 21].
Thus, in PMR/giant cell arteritis there also appears to be an inadequate cortisol secretion in relation to inflammation in terms of relative adrenal insufficiency.
Also, synthetic GCs - as applied in GC therapy - can cause negative feedback regulation, leading to adrenal suppression in terms of tertiary adrenal insufficiency [ 21].
The largest and more recent prospective multicentre trial (n = 2033 patients) comparing rolofylline versus placebo in patients with acute cardiac insufficiency did not find beneficial effect of rolofylline in terms of survival, cardiac and renal function [199].
To estimate the quality of life of patients in terms of the Chronic Venous Insufficiency Quality of Life Questionnaire CIVIQQ) score in both groups at baseline, and 5 and 9 weeks after starting the treatment.
