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The information about the sensitivity of the various instruments to changes in depressive symptoms may be useful, in that the most sensitive instrument will permit studies with the smallest sample sizes.
The aspects investigated were: the level of agreement between the health utility values generated by the instruments; instrument sensitivity (ceiling/floor effects and discriminatory ability); responsiveness of the instruments to changes in depressed state; and the acceptability of the instruments in terms of completion rates.
The objectives of this study were to estimate utility values in patients with OAB using the generic EQ-5D questionnaire and the OAB-5D disease specific questionnaire, to investigate the relationship between utilities and symptoms, and to evaluate the sensitivity of the two instruments to changes in symptom severity.
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However, the ability of these instruments to change attitudes toward conservation and their efficacy in affecting water use remains poorly understood.
Dudamel believes in the power of instruments to change the world because it changed him.
Overall, responsiveness of the instruments to change in reported outcome over time was in the range defined as small.
Our findings of a low sensitivity of the HRQL instruments to change in symptom burden is interesting and challenging both from a clinical and societal perspective.
There is less researchlooking at the responsiveness of instruments to change following treatment; in particular, there is insufficient research on how to develop instruments that are maximally sensitive to change.
Sensitivity is the response of the instrument to changes in analyte concentration or a measure of the ability of method to distinguish between small differences in concentration in different samples.
These equations predict the expected response of the instrument to changes in sample refractive indices.
Furthermore, testing the sensitivity of the instrument to changes over time is needed to evaluate treatment effects.
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