New statistical methods and new ways of conceptualizing and developing QOL instrument may be needed to achieve this.
This may have cost implications for large cohort studies where repeated measurements, more labour intensive instruments, or biomarkers may be needed for a large subsample in order to provide adequate precision to adjusted estimates.
In clinical practice, there may be circumstances when the child is too young, or too ill too complete an instrument, and parent proxy-report may be needed in such cases.
While pediatric patient self-report should be considered the standard for measuring perceived HRQOL [ 35], there may be circumstances when the child is too young, too cognitively impaired, too ill or fatigued to complete a HRQOL instrument, and parent proxy-report may be needed in such cases [ 36].
While pediatric patient self-report should be considered the standard for measuring perceived HRQOL, there may be circumstances when the child is too young, too cognitively impaired, too ill or fatigued to complete a HRQOL instrument, and parent proxy-report may be needed in such cases [ 16].
However, while self-report is considered the standard for measuring perceived HRQOL, there may be circumstances when the child is too young, or too ill or fatigued to complete a HRQOL instrument, and parent proxy-report may be needed in such cases.
When a PRO instrument is modified, additional validation studies may be needed to confirm the adequacy of the modified instrument's measurement properties.
Although pediatric patient self-report should be considered the standard for measuring PROs, there are often circumstances when the child is too young, cognitively impaired, too ill, or fatigued to complete a PRO instrument and a parent proxy-report may be needed [ 17].
Painkillers may be needed.
