Taking into consideration the complementary nature of these different kinds of instruments, disease-specific and generic instruments are in practice often used in tandem.
Health Related Quality of Life (HRQOL) instruments need disease and country specific validation.
Comprehensive clinical information is collected with these instruments, including disease diagnoses.
In this overview of SRs, we have focused on instruments involving disease related QOL and health related QOL.
Often, assessment instruments are disease specific [ 16, 17] and many measure only one or some empowerment related outcomes [ 18, 19].
Non-preference-based instruments (often disease-specific questionnaires) are commonly mapped to utilities.
This systematic review examines the trends in outcomes instruments, specifically disease-severity and QoL instruments, in randomized controlled trials (RCT) in the treatment of AD published between 1985 to 2010.
There are generally three types of QoL instruments: generic, disease-specific, and condition-specific.
The review identified a total of 12 instruments (10 disease-specific, 2 condition-specific) validated in long-term BCS.
In addition, all patients were screened for organ involvement according to the recently established assessment instrument for disease activity in pSS (European League Against Rheumatism Sjögren's syndrome disease activity index (ESSDAI)).
