The question therefore comes down to the issue of whether selecting a faster declining patient group, which generally increases the mean to SD ratio of an instrument (by increasing both the mean and the SD, but increasing the mean more than the SD), will also result in an increase in effect proportional to the increase in the mean placebo decline.
This means that any IV can be strengthened from a "weak" instrument to a "strong" instrument simply by increasing the sample size.
The IE-MS approach provides a simple and reliable technique that greatly enhances instrument performance by increasing the effective depth of MS-based proteomic profiling.
This trend could not be weakened by improved tuning of the instrument, e.g., by increasing the laser energy (data not shown).
Non-homogeneous standard deviations (p = 0.00001) in the group of MTI instruments, as denoted by increasing values over time during November, January, and March, indicates a reduced inter-instrument reliability over time for all settings jointly (Table 4).
Although a nonlinear hearing instrument can compensate by increasing amplification for soft sounds, it cannot compensate for the loss of suprathreshold abilities such as impaired frequency resolution.
In anesthetized, mechanically ventilated and instrumented pigs, HCA was induced by increasing the inspired fraction of CO2 (n = 8) and MAC (n = 8) by the infusion of HCl, to reach an arterial plasma pH of 7.1.
There was a statistically significant trend of decreasing HRQOL by increasing level of deprivation which was identified by both instruments (P < 0.05).
By increasing the number of variants, the proportion of variance explained by the instrument increases, thus improving precision in two-stage least-squares regression (Box 1) (50).
CcO activity was determined at 25°C in a closed 200 μl chamber containing a micro Clark-type oxygen electrode (Oxygraph system, Hansatech Instruments) by increasing the amount of substrate cytochrome c.
