There are three main approaches to describe and measure HRQoL: Disease-specific instruments, generic instruments and utility instruments.
If one can transform QoL-AGHDA scores into EuroQol scores, then outcomes of the QoL-AGHDA would be comparable with other (generic) QoL instruments, and utility for the use in health economic analyses would be available.
However, the relationship between VA and HSUVs is not the same between conditions or affected eyes, and is strongly related to the instrument and utility elicitation methodology used for HSUV elicitation.
We also compared the correlation between the general health scores from the cancer-specific instruments and the utility indices from the preference-based instruments.
In the case of incontinence, a number of studies have shown that commonly used generic HRQOL instruments and multi-attribute utility instruments (MAUIs) are relatively insensitive to health dimensions that are affected by the treatment of UI [ 12– 12].
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An MID has been reported for some generic health instruments; Drummond reported an MID in utilities of 0.03 for the 15D instrument and the Health Utilities Index (HUI®), with the elaboration that utilities of 0.01 may be meaningful in some contexts [ 48].
Several multi-attribute utility instruments and quality weight tariffs are available: EuroQol-5 dimension (EQ-5D) [ 3], Health Utilities Index Mark 2 and 3 [ 4, 5], Quality of Well-being Scale [ 6], and short form (SF -6D [ 7].
We restricted our search to specific utility instruments and conditions.
In regards to evaluation of validity, another limitation of our study is that we did not generate a priori predictions regarding correlations between the utility instruments and other measures.
Additionally, the instrument's content and utility was evaluated by an independent multi-disciplinary panel with expertise in gerontology, epidemiology, biostatistics and health services research and a plain language expert was commissioned to revise the instrument for clarity and readability.
