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In this chapter, we describe the fundamental information DSC provides for protein therapeutics, a description of the instruments and parameters of their use, and finally common DSC applications within the biopharmaceutical setting.
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Well designed studies are highly expensive and have to take into account standards, preparative methods, sample splitting techniques and so on, as well as the instrumentation and parameters of instrument usage.
The instrument configuration and parameters are then optimized for this particular mission.
We also provided the Excel template for users to adapt this library to their own instrument features and parameters and export customized libraries.
The Header defines the type of spectrum, the source of the data, the instrument type and parameters as well as the dataset that follows in terms of start and end positions of the X values and deltaX.
Sample preparation, instrument settings and parameter characterization are described in detail in Costa et al. [ 7].
DFe concentrations were measured by flow injection with online preconcentration and chemiluminescence detection using the exact protocol, instrument, and analytical parameters as described previously50.
Additional descriptions of the instrument and the parameters selected are given elsewhere [6].
Standard bryostatin 1 samples were analyzed using the same instrument and method parameters listed above.
However, the SNR of ASL is low, and as described above, results of ASL are sensitive to the subjects' postures and instrument parameters, and so forth.
In addition, information about samples, sample location (relative to introduction into an instrument), analytes and instrumental parameters are stored with the raw instrument data.
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