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Since that time, continuing advances in the analytical technologies for metabolomics (including improvements to instrumentation sensitivity, enhanced separation capacity, better software and more compound standards) have occurred.
Significant improvements in instrumentation (sensitivity, throughput, resolution of separation) [ 9], sample processing [ 11], and bioinformatics [ 22, 23] help comprehensive proteome profiling.
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Further advances in instrumentation and sensitivity of metabolite profiling should expose additional metabolites that characterize cumulative damage.
To account for possible confounding by instrumentation method, sensitivity analyses reprised all multivariable analyses by including a covariate for NHANES two-year wave of data collection.
PET systems designed for specific applications require high resolution and sensitivity instrumentation.
What is more, colorimetric sensors merely need minimal instrumentation, achieve high sensitivity, and thus can make on-site detection even easier.
Although several analytical techniques have been employed in the determination of H2O2, such as titrimetry [8], spectrometry [9], and chemiluminescence [10], most of them exhibit shortcomings like sluggish response, complicated instrumentation, and low sensitivity and selectivity.
In the development process of portable detection devices, the tradeoff between the size of the instrumentation and detection sensitivity is an important consideration.
Aiding in these efforts is the increased availability of liquid chromatography tandem mass spectrometry instrumentation featuring improved sensitivity and selectivity, as well as the use of stable isotope-labeled analogues for quantification of target compounds.
A study using ophthalmological instrumentation to measure color sensitivity would provide objective, 'hard' evidence of the association between color sensitivity and depression.
Use of more sensitive instrumentation, such as inductively coupled plasma mass spectrometry (ICP-MS) with sensitivity in the nanogram per liter range, is necessary to accurately assess removal of NPs and metal ions from drinking water.
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