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Due to the inherent HEV structural flexibility (as contributed by its flexible surface spikes) and the instrumentation limitation of electron microscope, cryo-EM alone was not able to solve the HEV VLP structure to high resolution.
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Posture, vision, and instrumentation limitations are the main predicaments of conventional laparoscopy.
Depending on devices employed in the experiments, the instrumentation limitations must be taken into account in order to ensure the accuracy of the measurements.
Commercially available noise dosimeters do not perform properly in impulsive noise environments because they suffer from instrumentation limitations and lack metrics that characterize impulse noise.
Although those methods offer a high degree of specificity, the instrumentation limitations preclude their use in routine analysis.
In terms of instrumentation, limitations arise from the linear range of the mass spectrometer and the sample capacity of the liquid chromatography.
However, miniaturization of a mass spectrometer would sacrifice its performance due to simplified instrumentation and limitations on power and size.
The proposed "half-interval search" method has many advantages, i.e., didn't rely on any instrumentations, avoided limitations of devices/sensors, and maintained high quality of test accuracy.
While HRFM has good spatial resolution and high collection speed using current instrumentation, the current limitation for in vivo HRFM of lymph nodes is depth penetration.
Currently available commercial CE instrumentation is limited to an applied voltage of approximately 30 kV and a maximum electric field strength of 1 kV/cm due to design limitations.
Vibrational spectroscopy can furnish high-throughput instrumentation without the limitations of the traditional techniques.
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