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These studies were not only instrumental to decipher structural properties of α-Syn associated with inclusion formation [9], [10] but they also allowed to confine α-Syn-mediated toxicity to the impairment of protein quality control systems and defects in ER-to-Golgi vesicular transport as well as endocytosis [31], [32], [34], [35], [36].
Further characterization of these isolated subpopulations will be instrumental to decipher which factors determine infiltration into solid tumors and will help to improve cellular therapies of solid cancers.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com