Sentence examples for instrumental pathway from inspiring English sources

Enrichment through the instrumental pathway occurs when the resources obtained in one role directly improve performance in another role.

A thorough understanding of this would be instrumental in designing pathway specific inhibitors of NFκB for the treatment of specific human ailments.

MiR-4732-3p was predicted to target both SMAD2 and SMAD4 [ 11], components of the TGF-β pathway instrumental in fine-tuning proliferation for efficient erythropoiesis [ 12].

This concept has been instrumental in understanding pathways leading to cancer, where mutations in any component of a given equivalence group (also called a core pathway) are mutually exclusive and tend not to co-occur in the same tumour [ 41, 42 ].

EPHB2 (Ephrin Receptor B2) are instrumental in signaling pathways like MAPK mediating tumour suppression, progenitor cell proliferation etc. [ 1, 2].

GEM models of UCC (Table 1) are important research tools and have been instrumental in elucidating pathways of bladder cancer (Wu, 2005).

This novel model allows, for the first time, longitudinal studies of human islet adaptation to an obese murine environment and may be instrumental in deciphering pathways involved in human beta cell expansion, as well as in helping to identify factors predisposing human beta cells to undergo decompensation [ 1].

The same study has shown that in rat brain tissue homogenates as well as in primary cultures of rat cortical neurons high concentrations of genistein decrease the expression of the 32 kDA caspase 3 precursor and increase the levels of the cleaved active form of this caspase that is well known to be instrumental in the apoptosis pathway.

Accordingly, we provide evidence that the atRA signaling pathway is instrumental in AHR signaling in the palatal region, notably through controlling Ahr transcript levels [see Supplemental Material, Figure 3 (http://dx.doi.org/10.1289/ehp.1003075)].

Likewise, mutants deficient in ABA levels have been instrumental in revealing the pathway by which ABA is synthesized in plants (Nambara and Marion-Poll 2005; Taylor et al. 2005).

A genome-wide experimental approach is instrumental in dissecting metabolic pathways important for increasing rice productivity and nutritional content.