However, these techniques usually require multistep sample preparations (hydrolysis and derivatization), instrumental modification, or special equipment, and have limitations, in that most of these methods cannot assign the double bond positions with accuracy and efficiency.
These methods are also instrumental for modification of target genes including gene truncations, site-specific mutagenesis and domain swapping.
He was instrumental in the design modifications that have been implemented over the last two years in an attempt to maintain Wild Oats's supremacy.
He showed that PKM2-dependent histone H3 modifications are instrumental in EGF-induced expression of cyclin D1 and c-Myc, tumor cell proliferation, cell cycle progression, and brain tumorigenesis.
The parameters % MDF decrement correlated significantly and negatively with the number of TPs, linking a clinical index with an instrumental measure of muscle modification.
In the hypercapnia group, we increased the instrumental dead space, without any modifications of tidal volume or respiratory rate, to maintain the PaCO2 in the range of 55 to 70 mm Hg.
If the no-effect modification assumption holds, similar instrumental variable estimates acquired using independent instruments would provide suggestive evidence against an influence of pleiotropic effects, as it is unlikely that they have shared pleiotropy [ 21, 35].
Surface modification techniques have been instrumental in the development of scaffolds that promote cell-surface interactions.
Combination of all this information with publicly available expression, DNA methylation and histone modification data can be instrumental for answering questions on epigenetic regulation and inheritance and unveiling long-range patterns of gene regulation and disease development [ 17, 19, 137].
