These changes in heterochromatin organization are important in the regulation of cell differentiation, senescence, aging and cellular transformation and might be instrumental for the function of Raf in these cellular processes (Fig. 6).
The sequence similarity of N domains, which are presumably instrumental for the function of all CEA-related proteins, differs dramatically among the ancestral genes with CEACAM16 being the most highly and CEACAM1 the least conserved member.
The extraordinarily strong deflective effect obtained in the low light intensity treatment with a UV component (Low, UV+) cannot be translated directly to natural conditions at dawn or dusk but suggests that the light conditions are instrumental for the deflective function of marginal eyespots in butterflies.
Nonetheless, here we present novel evidence that marginal eyespots in butterflies can deflect predator attacks, and suggest a possible mechanism, where ambient light conditions are instrumental for the anti-predator function of such features.
Repair of the denuded endothelium might be instrumental for the restoration of endothelial function.
The number of model organisms or cell lines with defects of the gene encoding for Pol ι, which are instrumental to understanding the function of this DNA Pol, is limited.
Estimation of cost-to-go functions is instrumental for the optimization of network control strategies.
The GPS comprises the central structural element of aGPCR function that could be instrumental for the conversion of an adhesive event into receptor output through G protein signaling, whereas the proteolytic nature of the GPS is not required for this activity.
Despite the fact that specific lipid environment is instrumental for some functions of uPAR [4] [5], flotation analyses combined with internalization assays clearly showed that endocytosed uPAR did not partition in low density fractions of sucrose gradients, and lipid-rafts disruption by methyl-β-cyclodextrin did not affect either uPA-PA1-dependent or the constitutive uPAR endocytosis.
Intuitively, one can hardly argue against the importance of these non rich-club nodes that consist of other subcortical regions (caudate and pallidum) [27, 28, 29], regions instrumental for sensori-motor function (paracentral lobule) [16, 30, 31], and regions known to be part of the limbic system (components of the cingulate) [32, 33].
