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Thus NeuroD6 may constitute an instructive target towards the design of novel therapeutic strategies for the treatment of neurodegenerative diseases characterized by a mitochondrial deficit and oxidative damage.
Our long-term goal is to understand what happens in the brain to cause motor learning when an instructive target motion is repeated many times.
Additional evidence for the existence of CS-linked plasticity during learning comes from analysis of trial-over-trial changes in simple-spike firing rate at the offset of on-direction instructive target motion.
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Methylation analysis on a genome-wide scale by means of a combination of immunoprecipitation of methylated DNA, microarray technology and bioinformatics has shown that cancer-related de novo DNA methylation comes about through an instructive targeting mechanism.
In Figure 2D,E, and all subsequent graphs, time zero on the x-axis indicates the time of the instructive change in target direction.
More sensitive, targeted, and instructive strategies employing advanced molecular probes could significantly enhance the early detection of MS lesions, possibly even in preclinical stages.
(B, C, E and F ) Each graph plots the average simple-spike firing rate for trios of trials with different blends of the presence or absence of CS responses to an instructive change in the direction of target motion.
TRAIL targets tumour cells for instructive cell death via the cell-surface receptors TRAIL-R1 (DR4) and TRAIL-R2 (DR5), which initiate the formation of death inducing signalling complexes (DISCs) ultimately leading to the activation of the caspase cascade [ 21].
But even when he's off target, it's always interesting and instructive to watch how he aims.
When free rider/cooperator is included as an orthogonal dimension, it will be instructive to see if tenure categorization obtains among targets who are free riders.
To avoid punishing the monkey for his inescapable response latencies in learning trials, fixation requirements were suspended for the 250 ms between the onset of target motion and the time of the instructive change in target motion.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com