Exact(2)
If simple-spike firing rate acts through inhibitory neurons in the deep cerebellar nucleus to modulate the response of inferior olive neurons to a given instruction, then a learned response in the cerebellum could modulate its own instructive inputs (Schweighofer, et al., 2013).
We put the approaches from our prior papers together in a way that (i) elucidates the multiple components, including CS-linked short-term plasticity, that cause trial-over-trial depression of simple-spike firing rate, and (ii) provides neural and behavioral evidence that the cerebellum may control its own instructive inputs in a way that would modulate cerebellar learning capacity.
Similar(54)
The mouse lumbar spinal cord has become a model system in which to study locomotor function because the underlying neural networks can be activated chemically or electrically and studied in the absence of an instructive input drive.
We conclude that some past learning inhibits future learning, as predicted if a learned depression of Purkinje cell simple-spike responses inhibits instructive climbing-fiber inputs.
Three features of our data support the idea that learned changes in the responses of Purkinje cells could modulate their own instructive climbing fiber inputs (Mauk and Donegan, 1997; Kenyon et al., 1998; but see Zbarska, et al., 2008).
This remark is instructive.
Based on the Marr-Albus motor learning model, input from mossy fibers encodes learning information in terms of contexts and stimulation while input from climbing fibers provides either positively or negatively instructive signals to modify the efficacy of the input from parallel fibers to Purkinje cells [48], [49].
It is instructive to consider the wide variety of inputs needed, even for such a relatively simple decision problem.
The climbing fiber input to the cerebellum carries instructive signals appropriate to guide learning during both low- and high-frequency training, whereas the Purkinje cell simple spikes carry useful instructive signals only during low-frequency training [21].
Studies on solute transport under different pore water velocity and solute input methods in undisturbed soil could play instructive roles for crop production.
It is instructive to investigate the outputs in response to varying the level of alternative inputs.
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Justyna Jupowicz-Kozak
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