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To find out whether the bi-functional nature of BMs has an instructive function in organizing the tissue architecture of the developing nervous system, segments of human BMs were inserted into (a) the parasomitic mesoderm of chick embryos, intersecting with the pathways of axons and neural crest cells, or (b) into the midline of the embryonic chick spinal cord.
The rules were extracted in forms suited to the instructive function of the interface.
Restoring CTCF reinstates proper architecture on altered chromosomes, indicating a powerful instructive function for CTCF in chromatin folding.
Of course, the instructive function of school is still important, but, at the same time, the school has the role to regulate the social behaviours, by educating the emotional responses and developing students' social abilities.
Our results suggest that dopamine plays an instructive function in aversive learning, possibly conveying information about punitive stimuli.
The second assumption ascertains that each endogenous amine has a double action: on the one hand, it would mediate the reinforcement signal throughout training, i.e., an instructive function (sense [38]) and, on the other hand, it could interfere with the opposite learning when there is temporal coincidence between the amine release and the consolidation phase of the opposite learning.
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Such instructive functions by the Rb family during cell fate determination may no longer be required once a cell becomes committed to a specific lineage, and the major function of Rb in committed cells might be to allow proper cell cycle exit and survival; a function that can be bypassed by survival factors or hypoxia.
During that Cultural Revolution, medical schools ceased their routine instructive functions and no new students were admitted between 1966 and 1970.
It is still under debate, whether cytokines have a rather selective than a lineage-instructive function during the commitment of multipotent hematopoietic progenitors (reviewed in Endele et al, 2014).
The function of DmelOBP44a and DmelOBP19d should have an instructive role for the research of Cmeg23484-c0 and Cmeg32081-c4 in aging and nutrient sensing.
Taken together, these results posit an instructive role for activity in the development of the visual system and uncover potential functions for heterosynaptic plasticity in sensory representation refinement.
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