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Altogether, these data define miR-8 as an instructive factor timing terminal differentiation.
Moreover, having a pump with the opportunities it offers to fine tune the administration of insulin might itself be an instructive factor.
Because these axons cross the CNS midline prior to undergoing ipsilateral collateral axon branching, it is possible that a midline extrinsic instructive factor acts retrogradely to induce collateral branch formation or that an instructive cue is presented by callosal axons from the contralateral hemisphere.
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However, the overall neurogenesis remained comparable (Fig. S3) among the control and the treated groups thus suggesting that, the ES cells differentiating into neural lineage following the said strategy could generate optimum neural derivatives without any exogenous instructive factors.
Moreover, as mir-8+ enteroblast cell numbers increase in response to cell loss/damage, these data further define miR-8 as an instructive "timer" factor of terminal differentiation.
A complex network of mechanisms involving induction of lineage instructive transcription factors, installation or removal of histone modifications and changes in the DNA methylation pattern locally orchestrate the three-dimensional chromatin structure and determine cell fate.
Ex vivo cultured cells can be transplanted with or without cultivation in a bioreactor or an in situ tissue regeneration strategy can be followed for endogenous cell homing with the recruited factors such as instructive scaffolds and/or signalling factors can be used.
Therefore, it should be instructive to compare factors affecting road safety in the U.S. and the best-performing countries.
Justice Powell's distinction between the medical school's rigid 16-seat quota and Harvard's flexible use of race as a "plus" factor is instructive.
A structural view of the virus-receptor interaction or at least of the receptor would be more instructive about whether additional factors are involved in the attachment step.
These findings are consistent with an instructive role of transcription factors in the establishment of cell fates.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com