The pMN domain is specified by the instructive activity of the secreted protein Sonic hedgehog (Shh), which, signalling through the canonical Gli pathway, provides positional identity to neural progenitors by directing a transcription network in responding cells.
These effective preschool settings also managed to achieve a balance between "teacher-initiated group work" and "freely chosen, yet potentially instructive, play activities" (p. 720).
Thus, intentional teaching is integral to play environments but it is the combination of intentional teaching with "freely chosen yet potentially instructive play activities" that makes a difference to children's learning (Sylva et al., 2003, p. 5).
In particular, we show how a coarse form of this connectivity pattern can be generated without any instructive electrophysiological activity.
We reveal that SHH establishes a permissive state for FGF-instructive action on hairy2 expression through fine-tuned Gli3-A/Gli3-R activity.
As always, the language of an activity is instructive.
All these results further confirm an instructive role of neuronal activity in regulating the dynamics of resting microglial processes and the formation of microglia-neuron contact.
We not only demonstrate an instructive role of neuronal activity in resting microglial motility, but also reveal, for the first time, a previously unappreciated function of microglia in homeostatic regulation of neuronal activity in the healthy brain (Fig. 2).
It is instructive to compare the catalytic activity of PW/KSF with different extractants (EtOH, DMF and MeCN) in the oxidation process (Fig. 3).
In addition, MTA1 possesses an inherent histone amplifier activity with an instructive role in impacting the epigenetic landscape, providing a new perspective to the molecular governance of dual coregulator functions of a master coregulator.
