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Activation of TLR signals on DC during vaccination instruct the generation of effector and memory lymphocytes [1], [16].
As besides Wnt signaling, IL-7 and IL-15 can also instruct the generation of TSCM cells, our findings suggest that ex vivo PGE2 treatment of UCB T cells might promote the generation of TSCM cells in vivo by enhancing Wnt/β-catenin-mediated signals and IL-7/IL-15-mediated signals.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com