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However, others have expressed concern that the reliability of public reporting systems may be compromised by institutional variability in the definitions used for HAIs, or in the methods and resources used to identify HAIs.
To minimize the impact of institutional variability, we included imaging studies only if they had been read originally by 1 of 3 certified nuclear medicine radiologists.
The natural history and optimal treatment of recurrent glioblastoma is not well-defined due to lack of uniform definition and criteria for tumor recurrence, institutional variability in treatment strategy and the heterogeneous nature of the disease including location of recurrence.
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While there is inter-institutional variability, the standard imaging protocol emphasises T2-weighted and gadolinium-enhanced T1-weighted sequences (Table 1).
Inter-institutional variability is inevitable due to the nature of a multinational study.
Possible reasons are the complex nature of this disease (which is multi-focal and heterogeneous) leading to frequent misclassification of patients, intra-institutional variability, and patient variability, all of which contribute to the lack of well-defined and validated prognostic biomarkers.
The statistics show that the variability of the data relative to the institutional data is quite different across institutional variables.
From the phantom study, a calibration factor was calculated by dividing the actual SUV by the measured mean SUV in the phantom background to reduce inter-institutional SUV variability.
Similarly, measures such as LOS and resource utilization may have institutional and seasonal variability.
It involves multiple policy domains, and features different institutional arrangements and variability in terms of geographical scope and main subject matter.
Second, even in cases where resectability status was based on laparotomy, there was institutional and surgeon variability with regards to expertise and definitions of resectability.
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