Per institutional routine, toxicity data were collected through Day 100.
A concept at the core of my argument is the known toxicity of institutional betrayal.
Further on, when the MGH approach was tested in a multi-institutional setting (RTOG 9514), toxicity was even higher and outcomes were clearly worse than expected from the MGH experience [ 22], although the results continued to compare well with historical data given the highly unfavourable group of patients included.
40– 43 Investigators assessed baseline "toxicity" according to institutional and previously published guidelines, 44 which included establishing baseline neutropenia and other bone marrow deficiencies as a result of AML.
Since one key advantage of BCT over mastectomy is the potential preservation of the appearance and sensation of the breast, recent institutional reports of adverse cosmesis and toxicity from APBI using 3D-CRT [ 30, 32] have been received with concern.
To the best of our knowledge, the current study is the first prospective, multi-institutional, phase 2 trial to demonstrate low toxicity in concordance with favorable FFLP with the delivery of gemcitabine and fractionated SBRT among patients with LAPC.
"CamoMan" lies prone, off by himself writhing on the ground in an apparent death throe, and speaks to the toxicity of not only individual, but also institutional and national aggression.
In the absence of large randomized studies, institutional case series can provide useful insights into the efficacy, toxicity and management of patients receiving novel agents.
Although this off-label use was approved by the institutional review board and all patients provided informed consent, the intradermal toxicity or tolerance of Gd-DTPA needs future investigation.
Specifically, 7 patients (11%) in the current study discontinued therapy because of toxicity, whereas 11 patients (31%) in our single-institutional study (Vredenburgh et al, 2007b) and 14 patients (18%) in the randomised study (Friedman et al, 2009) discontinued bevacizumab plus irinotecan because of toxicity.
