To determine the feasibility of RNA collection in a multi-institutional cooperative group setting to be utilized for micro-array gene expression analysis, and to describe the methodology.
To evaluate gene expression patterns in patients with advanced cervix cancer before and during chemoradiation in a multi-institutional cooperative group setting.
Clinical research is facilitated via participation in a large multi-institutional cooperative group (Cancer and Leukemia Group B), and through institutional programs in leukemia, bone marrow/stem cell transplant, gene therapy, immunotherapy and novel chemotherapy.
Video-assisted wedge resection and local radiotherapy for peripheral lung cancer in high-risk patients: the Cancer and Leukemia Group B (CALGB) 9335, a phase II, multi-institutional cooperative group study.
The results of a larger multi-institutional cooperative group trial comparing adjuvant standard-dose temozolomide and dose-dense temozolomide have also been reported [37].
18 It is noteworthy that the results of this pilot study (ie, 86% and 100% patients achieving normalization of PUA levels after 24 and 72 hours, respectively) were later confirmed in the multi-institutional, cooperative group setting.
A late phase II study of a new camptothecin analogue, irinotecan hydrochloride (CPT-11), was conducted to evaluate the anti-tumour effect and toxicity in patients with refractory leukaemia and lymphoma including adult T-cell leukaemia (ATL -lymphoma, in ATL -lymphomatutinnal cooperative study.
18, 20 A prospective multi-institutional cooperative group trial Z-03600) carried out in the US and sponsored by the American College of Surgeons Oncology Group (ACOSOG), involving 25 institutions over a 3-year period, assessed 140 patients with T1 and T2 oral cavity carcinoma.
All patients underwent IRB-approved treatment for their primary disease under institutional or cooperative group protocols.
All patients underwent treatment for their primary disease per institutional or cooperative group protocols.
Further researches will investigate as to whether new radiation techniques or different study cohorts (combining multiple institutional or cooperative group data sets) could be further validated this finding.
