Eligible subjects were singleton neonates, born at the three institutions of the study, weighing 1300 to 1800 g and clinically stable.
The data on malaria positive records of the healthcare institutions of the study site were transferred to Excel spreadsheet, checked for completeness (date of diagnosis, test results, patient age and address), coded; then, prepared data of malaria cases were exported to STATA statistical software version 12. Episodes of malaria were considered instead of number of cases for the analysis.
Ethics board approval was obtained at all participating institutions before initiation of the study, and all participants gave written informed consent before enrollment.
In 1765 it began the first institution for the study of medicine in the state.
Written informed consent was obtained from each patient at the respective institution before the initiation of the study protocol.
The study protocol was approved by committees of all relevant institutions for the study of humans in research.
Institutional review board approval was obtained from both institutions prior to initiation of the study.
(In the United States many institutions for the study of psychoanalysis then required applicants to have medical degrees).
The institution of the present study, Dokuz Eylul University School of Medicine (DEUSM), has been implementing Problem-based Learning (PBL) in its undergraduate curriculum since the 1997 1998 academic year.
The Research Ethics Board (MUHC-11-036-PSY) of McGill University Health Centre, the participating institution, granted approval of the study protocol.
