Several alternative molecular forms of PrP are reasonable candidates for the neurotoxic species in prion diseases, although it is still too early to tell whether these or other ones will turn out to be the true instigating factors.
Instigating factors, such as obesity, age, genetics, pregnancy and trauma may all contribute to mechanical impairment of the oesophagogastric junction resulting in pathological reflux and accompanying syndromes.
As summarised in figure 3, instigating factors such as obesity, age, genetics, pregnancy and trauma may all contribute to mechanical impairment of the OGJ resulting in pathological reflux and accompanying syndromes.
The mechanisms of SAE are unknown, but possible instigating factors may be the early activation of the innate immune response and microcirculatory dysfunction that are common manifestations of severe sepsis [ 6, 7].
High BMI and osteophytes are possibly the early instigating factors that predict increasing severity of meniscal tears and then change in meniscal tears is associated with other structural changes such as meniscal extrusion, cartilage volume loss and BMLs.
Consequently, the instigating factors of violence -- occupation and Israeli control over the Palestinians' lives -- still exist.
