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The paper concludes that the current focus on achieving balanced PM systems is less critical in small firms and the key aim should be instead to stimulate strategically aligned improvement.
The present results suggest that such agents might be used, instead, to stimulate genes whose lack of expression in ER-positive/HER2-negative tumours (representing 50 60% of all breast cancers) might contribute to the poor response of these tumours to chemotherapy (Liedtke et al, 2009).
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However, in contrast to sulindac sulfide, the sulfone does not block cyclooxygenase-2 (Cox2), but is instead believed to stimulate protein kinase G (PKG) activity via inhibition of cyclic nucleotide phosphodiesterase (cNPDE).
Accordingly, R-Ras-GTP via RIN2/Rab5 specifically elicits the endocytosis of ECM-bound/active integrins from the plasma membrane while the concurrent association of RIN2 with active R-Ras and Rab5, which at steady state mainly occurs on EEA1-positive early endosomes, is instead required to stimulate the activation of Rac1 and the ensuing adhesion of ECs to ECM proteins.
It doesn't involve tablets, using instead magnetic fields to stimulate the brain.
Instead, they promise to stimulate the economy by investing in strategic industries, like solar power and "green" cars.
Instead of trying to stimulate short-term demand, the plan seeks to improve our long-term growth rate by boosting supply: increasing the pace of innovation, and making workers more productive and commerce more efficient.
Since glutamate was used instead of NMDA to stimulate hippocampal neurons in culture, control experiments were performed to compare the effect of NMDA and glutamate on AMPAR lateral diffusion.
He wants schools to "stimulate instead of discourage" and to give pupils more positive feedback.
Instead, VML injury appears to stimulate complement, Wnt and TGF-β signaling in a sustained fashion, which in turn activates fibrosis development.
In one sign of some stabilization in the Russian economy, the Central Bank on Tuesday lowered its refinancing rate for the second time in two weeks, indicating it is less worried now about a run on the ruble and can instead focus on trying to stimulate lending to businesses.
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