Because of high nephrotoxicity risk for elderly, a narrow-spectrum monotherapy treatment with benzylpenicillin was preferred for these patients instead of combination of benzylpenicillin and gentamicin.
For example, older patients are more likely to receive monotherapy instead of combination therapy that does not include agents that target specific molecules [ 29– 31].
Instead of combination chemotherapy with rituximab, other treatments including more intensive chemotherapy, up-front ASCT after the first remission, or other newly developed drugs are required to improve survival of the patients who are at high risk of relapse [ 7, 8].
If, during the replication of DNA, instead of normal combinations of complementary NABs other combinations are possible, the normal hydrogen-bonding pattern in DNA is altered and the sequence of bases in recovered DNA is different and leads to spontaneous mutations.
Gell-Mann and Zweig posited that they were not elementary particles, but were instead composed of combinations of quarks and antiquarks.
Instead of rewarding combinations on just one line, this new machine let players make winning combinations diagonally, vertically and, on later models, in zig-zags across the screen.
DAPC is related to principal component analysis (PCA) but instead of finding combinations of parameters to account for the variability in data (as PCA does), DAPC finds combinations of parameters that best account for variability between groups.
Instead of moralistic combinations of image and text, the viewer is treated to clever visual jokes that can trigger a host of amusing readings.
It is noteworthy that the variation in LLS is best explained by temperature, instead of by combinations of temperature, water and nutrient availability (van Ommen Kloeke et al. 2012).
Moreover, several significant narrow bands and other broad bands were selected to establish eight kinds of wavelength (broad-band) combinations, focusing on comparing the performance of the narrow-band combinations instead of broad-band combinations for rice supervising applications.
