However, instead of modulation or alteration of the p53 protein/gene, we observed DNA hypermethylation of its target genes and loci.
The function of eNOS can be altered in many disease states such as atherosclerosis, hypertension, and diabetes mellitus, in which case eNOS starts to produce superoxide anion (O2−) instead of NO, an alteration defined as "eNOS uncoupling" [ 125].
Moreover, using probabilities of alteration (instead of magnitude of change), in addition to differentiating between evidence of alteration and estimated fold change, prevents inter-array differences in range of log2 ratios and tissue mixture to get confounded with evidence of alteration.
And they have talked about changing the supermajority rule to 60 percent instead of two-thirds, an alteration that would render the Democrats meaningless on any partisan issue.
A novel approach is then illustrated, where it is shown that this mechanistic model can be accounted for as a turbulent scale alteration, instead of addition, which enables the classical dimensional analysis of a turbulent boundary layer to apply.
There are some cosmetic alterations: instead of the compact first-floor theater at Performance Space 122, where the first work, "Solo," was presented in September as part of the Crossing the Line festival, the new dance takes place in the larger upstairs theater.
Some of the earliest studies of genetic mutants actually involved chromosomal alterations instead of point mutations (reviewed by [ 1]).
The interactive tool offers medical management quantitative decision support to enable them to act proactively instead of reactively to expected alterations in patient mix.
Further studies are required to clarify the genetic alterations instead of P2RY8-CRLF2 fusion and/or JAK2 mutations, which may cooperate with IKZF1 deletion in these leukemic patients in Japan.
Latendresse et al. (2001) reported that the intake of a sodium solution was increased in offspring perinatally treated with NP (2,000 ppm in diet; > 200 mg/kg/day), but instead of focusing on CNS alterations, the authors' focus was the relationship between this increased intake and the renal toxicity of NP.
