By assessing DRP instead of occurring adverse drug reactions we intended to evaluate the "first" parameter on the cascade to identify potential risks for the patients.
Hyperammonemia symptoms (seizures or neurological dysfunctions) are difficult to differentiate from the pathology itself (epilepsy or bipolar disorder) and they can be misdiagnosed as therapeutic failure instead of an adverse event related to the use of VPA.
The procedure to calculate the Target fingerprints is the same as described before in ADE fingerprints or MACCS, but instead of considering adverse events or the structural keys, we listed now targets for each bit vector position.
Finally, we did not report treatment-related toxicities in this retrospective study because the physicians only recorded the most significant adverse effect in daily practice instead of recording all adverse effects as required in a clinical trial and this could have resulted in the underestimation of the minor significant adverse effects.
For example, instead of asking for "any" adverse effects, it will ask in detail about single adverse effects like bleeding, pain, and perforation in order to prevent the reviewer from assessing combined information.
When preparing financial reports, managers usually have a positive attitude or mood (instead of a negative or adverse emotional tendency) towards the company's financial position, operation results, and cash flow.
Hydromorphone or morphine were chosen for the epidural instead of fentanyl if an adverse reaction precluded the use of the latter.
A growing number of studies on the effects of HCA, both in experimental models and in patients, indicate that instead of being a tolerable adverse effect, HCA may exert direct protective actions and may be therapeutic by itself [ 1].
Many studies of diabetes have examined risk factors at the time of diabetes diagnosis instead of considering the lifetime burden of adverse risk factor levels.
Intravesical instillation of liposomal BoNT-A instead of injection could prevent such adverse events.
