Instead high levels of glutamatic acid, phenylalanine, and taurine were found in PCa bone metastasis tissue and in plasma from men with diagnosed PCa bone metastases.
This likely occurs in breast cancer, where NOTCH1 or FBXW7 manifest low mutational rates (Byrd et al, 2008; Mao et al, 2008; Ibusuki et al, 2011; Santarpia et al, 2012) and where, instead, high levels of Pin1 are frequent (Wulf et al, 2001; Girardini et al, 2011) and strongly correlate with activated N1-ICD.
Wild p53 levels in MCF-7 cells increased early in response to WEB-2086 with a peak at 3 h and then decreased progressively with time; instead, high levels of mutated p53 protein in MDA-MB-231 cells did not vary with treatment.
Instead, higher levels of significance may be accessed by using the extreme-value theory (EVT) to approximate the tail of the null distribution, thereby permitting considerable economy of computational effort [ 4].
Instead, higher levels of subjective pain and distress during delivery assessed at 1 month after delivery (β=.51, p < 0.001), depression during pregnancy (β=.15, p < 0.001) and history of life traumatic events (β=.08, p < 0.01) were found to be predict variables of PTS symptoms.
In contrast, RMS cells with low Ezrin expression and poor metastatic potential had diminished levels of acetyl-H3-K9 and tri-methyl-H3-K4 instead of high levels of di-methylation of histone H3 lysine 9 (di-methyl-H3-K9).
This finding, and detection of multiple lineages infecting individual bat species, may instead reflect high levels of transmission within and between bat species caused by crowded roosting areas and sharing of roosts by multiple species.
However, NIH3T3 cells do not express EGFR, the prototypical receptor tyrosine kinase commonly used to robustly activate Ras [ 43], but instead express high levels of PDFGR which is a poor Ras activator.
An alternative explanation is that instead of high levels of K14 and K23 acetylation being an important epigenetic marker, it could be key to not have disproportionally high levels of K18 during histone assembly, and that is why the acetylation pattern of CBP is more evenly distributed on H3 alone, although this has yet to be seen.
It is interesting to note the tumours that develop following H-Ras mutation and β-catenin activation have increased MAPK signalling (although not p-AKT/p-mTOR activation), while tumours that have PTEN loss and β-catenin activation show little MAPK pathway and instead have high levels of p-AKT/p-MTOR.
For example, instead of maintaining high levels of metabolism for temperature stability, poikilothermic species may lower their metabolic rate to cope with low external temperatures [ 12].
