In the latter instance, substantial ties means that your parent is a citizen of a British overseas territory, a Commonwealth citizen, US citizen, European Economic Area EEAA) citizen, British national or citizen overseas, and they would need to have demonstrable connections with the UK by way of family history or have been resident here for a substantial period of time.
For instance, substantial incentives and grants are provided in the HITECH Act for the adoption of EHR systems and information exchange to improve both quality and efficiency of healthcare.
All of them contain settlements, in certain instances quite substantial towns, and these bring all the infrastructural development ("exploitation") that modern life requires.
The lack of completely labeled training instances, imposes substantial challenges for MLC classification, especially in that most of the proposed relevant solutions do not deal with this problem [37].
A final point of note apparent from review of the graphical presentations is that, although in the majority of cases, animal-to-animal variability is greater than that seen within-animal, there are instances of substantial differences between measurements within the same animal.
The games don't vary much, which is why the high points tend to be cited as Mega Man 2 and Mega Man X, two instances where substantial change did happen.
These instances suggested substantial genomic restructuring or transposition.
This might explain why, in a few instances, a substantial part of cells was killed by trypsin after prolonged exposure to gefitinib.
Thus, we took care to ensure our analysis does not depend on whether we are at 100% saturation and instead focuses on the instances of substantial quenching.
