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Eight families showed instances of neolocalization.
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The type IB subfamily of DNA topoisomerases that includes DNA topoisomerase 1 (TOP1) and mitochondrial DNA topoisomerase 1 (TOP1MT) presents an example of neolocalization to mitochondria.
The arginase family, encoding enzymes that catalyze the hydrolysis of arginine to ornithine and urea, is an example of neolocalization to the cytosol.
This suggests that the elevated number of compartments for D-pairs (WGD-derived duplicates with distinct cellular localization) could be the result of neolocalization and not of a wide cellular representation of ancestral progenitor proteins, prior to duplication.
The complex functions of mitochondria demand a proteome composed of over a thousand of proteins, more than 98% of which are nuclear encoded, which suggests these organelles should play a major role in the process of neolocalization [ 23].
Furthermore, even when the number of neolocalization is the same in a duplicate gene and a singleton gene, the number for a duplicate pair is twice that for a singleton.
Instances of laughter?
There have been unfortunate instances of nullification.
All instances of vandalism are regretful.
Other instances of derivative acquisition are involuntary.
Were these instances of actual bullying?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com