On the basis of biochemical and functional considerations, the term autophagic cell death is used to indicate a death instance mediated by autophagy, suppressed by the inhibition of autophagy by chemicals and/or genetic means.
First, some compensation mechanism, for instance mediated by other Ctp proteins, may couteract ctpC deficiency; this may be addressed using mutants inactivated in several P-type ATPases, wich is ongoing in the laboratory.
Less clear is the relation, direct or indirect, that satellites may have with gene regulation although it is increasingly more suspected that such exists, for instance mediated by the chromatin [ 2].
It might for instance be mediated by views about the effectiveness of organizational communication.
For instance, phosphorylation mediated by protein kinase C (PKC) can suppress JH action by preventing nuclear proteins from binding to JH-responsive promoters [ 3].
Gro-dependent repressors also act downstream of receptor tyrosine kinase (RTK) pathways, for instance those mediated by the Torso receptor and by EGFR (Paroush et al, 1997; Price et al, 1997).
Significant discrimination between RNA and DNA bases, for instance, may be mediated by the conformational deformability of polymers and substrates.
In many instances, virus cell interaction is mediated by cell surface heparan sulfate proteoglycans (HSPGs).
In both instances, these processes are mediated by transmembrane cell adhesion molecules.
Cellular stress factors like for instance oncogenic activation, as mediated by HPV infection or constitutive activation of mitogenic pathways (e.g. KRAS mutation) trigger compensatory p16 up-regulation [ 13- 15].
