In these instances, interactions between mechanical components were generally linear and deterministic as well as readily perceivable and understood.
In three instances, interactions between active and inert ingredients were important (Oakes and Pollack 2000; Swann et al. 1996; Tang and Song 1996); three studies demonstrated that the increased toxicity was primarily due to the inert ingredients (Koyama et al. 1997; Oakes and Pollack 1999; Zeljezic et al. 2006).
For any possible pair of proteins, if they have a query domain instance pair (one domain instance on each of the two proteins), then these two proteins are predicted to be interacting with an interaction score equaling the domain instance interaction strength of that query domain instance pair.
Despite the importance of cooperative interactions in regulating biological molecular systems, they are currently not adequately captured in bioinformatics resources, for instance, interaction databases such as IntAct (26), the Database of Interacting Proteins (DIP) (27) and the Molecular Interaction database (MINT) (28), but also pathway databases like Reactome (29).
For instance, interaction and reaction of dislocations leads to formation of sessile dislocation structures that block subsequent dislocation motion; consequently, the resulting work hardening leads to increase of machining force.
These proteins may play some role in the nucleoid characteristics that require, for instance, interaction with the membrane.
This score is defined as the "domain instance interaction strength".
For instance, interaction between α5β1-integrin and fibronectin in T4-2 breast cancer cells is essential for therapeutic response [ 46].
Query domain instances with multiple possible template instances are scored based on the template with the best domain instance interaction strength.
If the protein pair has more than one underlying query domain instance interaction pair, then the query domain instance pair with the best score is used to represent the protein pair.
