Exact(4)
In both instances, binding motifs for multiple proteins were identified, many of which are specific to transcription factors.
In most instances, binding was either not RA-dependent or weakly enhanced by ligand, consistent with capacity of RARs to bind DNA in the absence of ligand [ 15].
There was no reactivity with hepatocytes but in some instances binding to fibrous tissues and in one case to portal tract lymphocytes was observed.
One feature for instance is the ability to self-associate, forming either oligomers or homo- or hetero-polymers or in some instances binding to RNA and DNA (Qiao etal., 2004; De Rycker and Price, 2004; Song et al., 2005; Aviv et al., 2006; Oberstrass et al., 2006; Qiao et al., 2006).
Similar(56)
However, unspecific background binding, for instance binding of non-target antibodies, is a common obstacle in such immunoassays.
For instance, binding interfaces of specific domains are known to be mapped to specific domains such as p21-activated kinase 6 (Pand) and tubulin to ROC, heat shock protein 90 (HSP90) to Kinase, or N-ethylmaleimide sensitive fusion (NSF) to WD4035,36,37,38.
For instance, binding models with multiple bound states, pH and/or temperature dependence of binding parameters, surface diffusion, and arbitrary spacing of the radial discretization have been recently added.
For instance, binding of N-acetylgalactosamine sugars to ASGPR is more effective than galactose.
For instance, binding of inhibitory KIR to MHC class I on target cells prevents the tyrosine phosphorylation of activation receptors 2B4 and NKG2D, as well as their recruitment to detergent-resistant membrane microdomains [8], [9].
For instance, binding of HP1 to heterochromatin is sensitive to digestion with RNase A [19] and it requires the contribution of the hinge domain, which is known to bind RNA in vitro [38].
For instance, binding sites accumulation may increase degree without affecting multiplicity.
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