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Analysis of the 31 promoters revealed that 3 TFBS motifs (Elk-1, RREB-1 and SPIB) were over-represented using the Clover criteria (p < 0.05) among all 8 promoter sequences of miRNA genes that are up-regulated in monocytes, and to have at least 1 high-scoring TFBS (instance score ≥ 6) in each promoter.
In addition, any mention of a TF motif score in subsequent sections refers to the instance score for the TFBS at a specific location in a promoter sequence.
Our thresholds for Clover outputs are instance score ≥ 6 for recognizing a specific TFBS, and p-value ≤ 0.05 for over-represented motifs (default values in Clover).
Besides the raw score, Clover also reports an instance score, which is the logarithm of the likelihood ratio mentioned above for any specific TFBS at any specific position in the sequence.
Each interacting query domain instance pair is scored according to the similarity of the interaction residues in the interaction interfaces, and the best query instance score is used to represent the interaction strength of the predicted PPI (how likely the two proteins in the PPI are interacting each with other).
Similar(54)
D-League games are typically high-scoring affairs — the Legends, for instance, scored sixty-eight points in the first half — but that, evidently, is not enough to hold fans' interest.
(Harris, for instance, scored a 22 on the ACT test — slightly above the national average and well below the U.C.L.A. average).
The 2001 Shafer Cabernet Sauvignon Anniversary SunSpot Vineyard, for instance, scored a 93.6 from CellarTracker's users and a drinking window that spans 2008 to 2025.
In online education, for instance, scores help schools winnow prospective students who are not worth the investment of expensive course catalogs or attentive follow-up calls — like people who use fake names or adopt the identities of relatives.
Mr. Lichtman, for instance, scored Mr. Obama as charismatic in 2008, but not John McCain (even though Mr. McCain, with his service in the Navy, might have met Mr. Lichtman's description of a "national hero").
The British electro-soul duo AlunaGeorge, for instance, scored a hit in the U.S. only when the Vegas club regular DJ Snake remixed one of their old singles, while vocalists like Jess Glynne and MØ boast popular collaborations with dance acts but hardly any American name recognition.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com