In a later phase, once LIDs have been established, hyper-activation of PKA/DARPP-32 may become sufficient to maintain their expression independently of ERK, most likely by short-term regulation of neuronal activity through, for instance, regulation of the state of phosphorylation of GluR1 and other ion channels.
For instance, regulation of synaptic plasticity and function has been shown to be associated with caspase-3 activation.
This does not rule out a role for global regulation of the synthesis rate, via, for instance, regulation of the overall GS levels at a transcriptional level.
For instance, regulation of kinase autophosphorylation by activation segment exchange between two adjacent catalytic domains was initially observed in the crystal structure of the kinase CHK2 [12].
For instance, regulation of the protein stabilization/degradation or ribosomal stalling during translation (which would produce RFPs but not functional protein product), could explain the lower correlation observed.
For instance, regulation of hb, Kr, gt, and kni by Bcd and Cad, and auto-regulation are all strongly correlated with their corresponding h a (see panels (a), b), c), and (d) of Figure 6).
The choice between both system modes should be cell type dependent, for instance regulation by the JAK/STAT3 pathway and resulting Bcl-2 expression control in the non-apoptotic state is known for hematopoetic cells [ 8].
Ltb4dh is of special interest because NSAIDs are known to inhibit the mammalian biosynthesis of various eicosanoids (e.g. prostaglandins, epoxyeicosatrienoic acids and leukotriene) that play important regulatory and signalling functions, for instance regulation of ion flux [ 14, 15].
But reducing those tariffs to zero and eliminating other barriers — by, for instance, harmonizing regulations — would provide important benefits to consumers and businesses.
