In most instances proteins are fused to the α-mating factor (α-MF) signal peptide from S. cerevisiae to target proteins to the secretory pathway.
In the Ion Channel dataset, the instances (proteins) are represented by their distance from each other (E-value).
For instance, while proteins are initially digested best in the harsh acidic environment of the stomach, starches are broken down most efficiently in the more alkali milieu of the small intestine.
For instance, essential proteins are synthesized on the rough endoplasmic reticulum and in the cytosol, while unwanted proteins are broken down in the lysosomes and also, to some extent, in the cytosol.
Furthermore, we make sure the drug is protein-free, as protein contaminations (for instance HMG proteins) are known to activate various types of immune and stem cells.
Detection of small proteins biochemically requires optimized approaches so that, for instance, small proteins are not simply run off gels during electrophoresis.
For instance, ribosomal proteins are frequently mutated in patients with Diamond-Blackfan anemia (DBA), but it is not clear how the ribosomal defects lead to the disease.
For instance, two proteins are involved in AD: amyloid beta, which is deposited in extracellular amyloid plaques; and tau, forming intracellular neurofibrillary tangles.
For instance, TFAP2 proteins are known to be modified post-translationally by phosphorylation, sumoylation and redox status, which may affect their activity and cellular localization [ 12].
The average number of instances (domains) per bag (protein) is 3.14 ± 1.19, and the average number of labels (GO terms) per example (protein) is 3.55 ± 5.00 (Table 2).
