Previous studies in other mammalian groups suggest that the brain represents another instance of tissue-specific regulation of imprinted loci.
However, these expression data also reveal several instances of tissue preferential expression that suggest roles in specific developmental programs.
Metformin should also be used cautiously in patients with conditions that interfere with the metabolism and excretion of lactic acid, such as heart failure and liver disease, and during acute illness and/or instances of tissue hypoxia (82, 83).
For instance, exposure of tissue factor (TF) and activation of TF-induced thrombin generation is now also considered to play a key role in thrombi formed in the arterial circulation [4], [5].
For instance, correction of tissue disposition data for the fraction of drug in the vascular compartment is possible if the blood PK and tissue Vv are known; this is particularly helpful for drugs having an interstitial or cellular site of action (i.e. biophase).
For instance, upregulation of tissue inhibitor of metalloproteinase (TIMP -1 increases bifurcaTIMP -1 the salincreasesnd [ 46] and induces higher numbifurcationnches in lung developmenthe 84], while in the mammary gland, upregulation of TIMP-1 leadsalivaryibition of ductal elonglandn without affecting bifurcation or higher-order branching [ 12].
DOI: http://dx.doi.org/10.7554/eLife.05003.007 In summary, our screen revealed countless new instances of tissue-specific gene expression and mRNA localization in the ovary.
It is well established that tumors can promote coagulation and platelet activation, for instance by expression of tissue factor [22].
For each tissue, the engine loops through every pixel of the image and replaces all instances of the tissue's colour key with the calculated colour using the replaceFill function we introduced to the Python Imaging Library (PIL, www.python.org).org
Previous studies demonstrated that netrin-1 can limit neutrophil and monocyte recruitment during instances of acute tissue injury.
Similarly, most instances of differential (tissue-specific) TE expression were seen in the sense orientation.
