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Hits or targets of a transcription factor were identified as those genes with a high confidence instance of the associated binding site in their 2000 bp upstream region (for details see Figure 2 and Methods).
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As a result, the motifs identified from the genomic regions that they bind often reflect the sequence homology among different instances of the associated ERE type, rather than the genuine binding preference of the C2H2-ZF protein.
The sequence order is subjectively selected by the analyst, based on several criteria as for instance the severity of the associated Top-event.
Racila et al. (2006) have also reported that rs172378 correlates with decreased complement activity, which then reduces the instance of metastasis associated with breast cancer, perhaps by resulting in an inefficient clearance of apoptotic tumour cancer cells, which consequently results in the development of a more effective antibody response against the tumour.
To obtain the instance of the guardian member associated with each participant (an instance of type GuardianMemberImpl), each interceptor employs the GuardianMemberFactoryImpl factory.
Each instance of the objects was associated with an element of activity (i.e., actor, instrument, environment, and artifact) according to the analysis framework shown in (Figure 1)The association was recorded at instance level (i.e., each appearance in the data) because one object could be categorized into more than one element, depending on the context where the object was mentioned.
To our knowledge, our case is the first instance of myeloid malignancy associated with 8q24 chromosomal translocation affecting MYC.
The second instance of PRES was associated with a presenting blood pressure of 160/100 mmHg, but no sign of underlying infection.
Not every instance of aneuploidy is associated with neoplasia.
One instance of the increased molecular complexity associated with SLTS is the evolution of polycistronic transcripts, which is tightly associated with SLTS in diverse eukaryotic lineages (and is very rare in eukaryotes without SLTS).
In the instances of this syndrome associated with dislocation of the hip, the response to abnormal position of the constituent parts of the hip joint is beautifully illustrated by the case of R.L.M. [ 2].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com