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While "caching" is certainly an instance of substantial reproduction, it is a technical process only; as such it does not consist in an attempt to appropriate the legitimate economic interests of the copyright holder, and therefore does not constitute infringement.
These are the conditions he sets for justified civil disobedience: it is undertaken 1) in response to an instance of substantial and clear injustice, 2) as a last resort and 3) in coordination with other minority groups.
It noted the expert's methodology to be "flawed" and stated that through its own analysis, no instance of substantial similarity was found.
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A final point of note apparent from review of the graphical presentations is that, although in the majority of cases, animal-to-animal variability is greater than that seen within-animal, there are instances of substantial differences between measurements within the same animal.
Thus, we took care to ensure our analysis does not depend on whether we are at 100% saturation and instead focuses on the instances of substantial quenching.
HIPK2 has an important role as a negative regulator of gene expression [40] and its elimination from promoter-associated repressor complexes allows for induction, for instance, of a substantial fraction of hypoxia-induced genes [24].
For instance, the concept of substantial equivalence in the US and Canada is interpreted less strictly than requirements in the European Union.
Although there are relatively few published studies that give dN/dS ratio estimates for large numbers of pseudogenes, in each instance a substantial proportion of the identified pseudogenes were found to have dN/dS values substantially less than 1.0 [24], [25], [26], [26].
For instance, a substantial fraction of the plaque core consists of cholesterol-esters (inside living and necrotic macrophages) originating from the synthesis of fat, cholesterol and lipoprotein particles.
For instance, a substantial amount of work has been carried out, from a number of different perspectives, on the factors that produce safe, high-performing teams.
Four years after the Haiti earthquake, for instance, a substantial proportion of US development funding in the country still goes via American, rather than Haiti-owned companies.
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